NONALCOHOLIC FATTY LIVER DISEASE IN OBESITY AND TYPE 2 DIABETES
Maint Content
In the healthy state excess fat is deposited at appropriate sites, such as subcutaneous fat
depots. When fat begins to accumulate outside these regular depots, within the liver and other organs, it is named ectopic fat. To discriminate hepatic ectopic fat from fatty liver due to alcohol abuse, the condition is termed nonalcoholic fatty liver disease (NAFLD). The exact pathophysiology of NAFLD is unclear, but the deposition of ectopic fat within the liver is increased in both type 2 diabetes (T2DM) and obesity.
Accumulation of ectopic fat severely impairs hepatic metabolism and without appropriate intervention NAFLD may lead to nonalcoholic steatohepatitis (NASH) and eventually to liver cirrhosis. Resulting from the dramatic increase in patients with T2DM and obesity worldwide, cirrhosis due to nonalcoholic fatty liver disease has been predicted to become the main cause for liver transplantation by the year 2020. This poses a great need for a better understanding of the effects of ectopic liver fat on liver metabolism, new pharmacological treatment options for NAFLD and new affordable and rapid methods for early detection of liver fat accumulation in patients at high risk for NAFLD. In the current study liver fat content and glucose uptake were studied non-invasively using proton magnetic resonance spectroscopy (HMRS) and positron emission tomography (PET) in patients with T2DM, patients with obesity and healthy volunteers. Liver fat content was found to be inversely associated with liver glucose uptake in patients with T2DM and also to be associated with impaired myocardial metabolism in these patients. In addition our data indicate that liver fat content might be significantly reduced by one month Trimetazidine treatment in obese patients. Finally, we were able to develop a new rapid method, using in-and-out-of-phase MR imaging, for the non-invasive assessment of liver fat content.
NONALCOHOLIC FATTY LIVER DISEASE IN OBESITY AND TYPE 2 DIABETES - Link Download
Keywords: nonalcoholic fatty liver disease, NAFLD, liver, proton magnetic resonance
spectroscopy, 1HMRS, positron emission tomography, PET, diabetes, obesity, rosiglitazone, trimetazidine, magnetic resonance imaging, MRI
- Alcoholic Fatty Liver Disease Treatment
- NONALCOHOLIC FATTY LIVER DISEASE IN OBESITY AND TYPE 2 DIABETES
Alcoholic fatty liver disease not unlike other forms of fatty liver is reversible. When the cause of fatty liver is alcohol, it is more likely to develop into cirrhosis and cancer, so it is very important to reverse it and prevent it from haunting you again.
Alcoholic Fatty Liver Disease Treatment
Alcohol damages your liver cells by overloading them with work. When that happens fat accumulates inside them because they can't handle taking care of both fat and alcohol (fatty liver, or steatosis stage). As more fat accumulates, less damage the liver can endure and cells start to die and be replaced by fibrotic tissue (cirrhosis stage). Fibrotic tissue does not function and leads to chronic liver failure. Damage to the liver also increases the probability of developing cancer.
But even when you already have alcoholic fatty liver disease, treatment is possible. The first step is, of course, reducing alcohol intake or, better yet, remove it completely. Alcohol not only damages your liver directly, but it is causes malabsorption of nutrients essential for liver recovery.
The next step is adjusting your diet. Make sure you eat a balanced diet and, if at all possible, become vegetarian. Meat, fish, eggs, and milk put extra load on the liver, which you want to avoid. On the other hand, fruit, vegetables, grains, and beans are rich in nutrients and poor in calories, providing the nutrients necessary for liver regeneration while keeping calories low to signal the liver to burn the fat inside it.
Finally, one last step is taking supplements. A few herbs have been proven to cause liver regeneration and fight liver cancer, and they have healed people with steatosis, cirrhosis and even liver cancer. The most important of these are milk thistle, and artichoke, but the list is very long. You can either try to take one supplement of each or, better yet, use one of the many combinations available.
Alcoholic fatty liver disease treatment is one of the best steps you can take towards health. It is beneficial for everyone who takes, or took, alcohol, because even moderate amount have been shown to cause some degree of liver damage.
Fatty liver disease treatment who
Treating non-alcoholic greasy liver illness (NAFLD) includes distinguishing and treating any basic conditions (for example type 2 diabetes), enhancing insulin opposition with way of life changes and medicine, and utilizing cell reinforcements to shield the liver from cirrhosis. Treatment will, be that as it may, rely upon the phase of the malady.
Weight reduction - Fatty liver disease treatment
On the off chance that you have NAFLD, the initial step is to continuously lose around 7-10% of your body weight. Weight reduction remains the best method to expel fat from the liver.
Aside from constraining your kilojoule admission and practicing most days of the week (doing both vigorous and weight-bearing activities), it's critical to restrain your admission of immersed fats (found in meat and other creature items), refined sugar (particularly sugar-improved refreshments and juices), handled nourishments, and liquor. Your specialist and additionally Fatty liver disease treatment dietician may suggest that you pursue a Mediterranean-style diet high in fiber and mono-unsaturated fats from fish, nuts, seeds, olive oil and avocado.
Specialists in some cases likewise use bariatric medical procedure to initiate weight reduction, enhance insulin opposition and enhance glucose digestion in people with non-alcoholic steatohepatitis (NASH), Fatty liver disease treatment an increasingly extreme type of NAFLD. In any case, these methods, amid which changes are made to the stomach related framework, should just be saved for individuals in whom intense weight reduction is required.
Medicine - Fatty liver disease treatment who
No medications have been affirmed to treat NAFLD explicitly. Notwithstanding, in the event that you have insulin obstruction or unmistakable diabetes, your specialist may endorse insulin-sharpening medications, for example, the thiazolidinediones or metformin. Prescription to treat elevated amounts of cholesterol and different sorts of fat in the blood (dyslipidaemia) and (hypertension) may likewise be recommended.
Your specialist may moreover prescribe that you motivate inoculated against viral hepatitis to shield your liver from further harm. The person Fatty liver disease treatment in question will likewise check in case you're not taking any drug that could be intensifying your condition, and stop or change that medication.
In the event that you've been determined to have NASH, and don't have diabetes or cirrhosis, your specialist may likewise suggest taking cancer prevention agents as nutrient E.
Pioglitazone, a diabetes tranquilize, may likewise be recommended.
Probiotics and basic phospholipids - fatty liver disease where is the pain
Probiotics and basic phospholipids (EPLs) are of developing enthusiasm for the administration of NAFLD.
Research demonstrates that a strain of microbes called Lactobacillus rhamnosus GG may secure against the advancement of fructose-incited NAFLD. Be that as it may, no firm proposals can be made so far fatty liver disease where is the pain and more research is expected to affirm the advantages of probiotics in the treatment of NAFLD.
Some examination ponders additionally show promising outcomes with fundamental phospholipids. Taken as enhancements, the phospholipids appear to have mitigating, cancer prevention agent and lipid-directing impacts in the liver, while recovering the liver cell layers.
Be that as it may, managing the serious issues of overweight and absence of activity stays key.
How can i cure fatty liver disease
Type 2 Diabetes - Preventing Non-Alcoholic Fatty Liver Disease
Non-alcoholic greasy liver infection is a genuine complexity of Type 2 diabetes. As indicated by an investigation from Johns Hopkins Bloomberg School of Health in Baltimore, United States, hormonal treatment could be one methods for aversion.
The investigation, gave an account of in the Journal of Gastroenterology in November 2012, included 4,338 ladies from 20 to 60 years old: a sum of 11.6 percent members were determined to have non-alcoholic greasy liver ailment.
How can you cure fatty liver disease -ladies taking oral contraceptives had just a 6.7 percent predominance of the infection.
members who detailed previously taking oral contraceptives had a 12.0 percent pervasiveness of non-alcoholic greasy liver malady, while ladies who had never taken the drug had a 15.0 percent commonness of the ailment.
From these outcomes, it was closed oral contraceptives could be related with a decreased possibility of creating non-alcoholic greasy liver infection, which would be steady with the reality young ladies are less inclined to get the ailment than ladies after menopause, and men.
Then again, the specialists alert ladies taking oral contraceptives could have less fat than ladies not taking the prescription. Further investigations will be expected to clear up whether hormonal treatment may be valuable to ensure the liver.
People with the illness can be without manifestations at the outset, yet as the condition propels they can wind up tired and get more fit for no undeniable reason. High blood dimensions of liver proteins are a sign of liver infection. The infection can be analyzed when a bit of the liver, called a biopsy, is evacuated and took a gander at under a magnifying instrument.
Non-alcoholic greasy liver malady can be quiet except if the liver winds up aggravated, a condition known as non-alcoholic steatohepatitis, or NASH.
NASH influences - how can i tell if i have fatty liver disease
How can non-alcoholic fatty liver disease be treated: 2 to 5 percent of Americans, much of the time happening in moderately aged, or fat people.
In the event that the liver ends up scarred and hard, the blood won't have the capacity to course through it and the liver would then be able to lose its capacity. In spite of the fact that the causes are not completely comprehended, insulin opposition, arrival of cytokines (particles additionally found in diabetes), and oxidation responses, all have all the earmarks of being identified with it. As of now, measures to keep the condition include:
- normalizing weight
- eating a nutritious, low-fat eating routine,
- getting enough exercise,
- maintaining a strategic distance from liquor, and
- maintaining a strategic distance from prescriptions that are not totally important.
Different medications for non-alcoholic greasy liver malady are under investigation. Metformin, pioglitazone, rosiglitazone, selenium, nutrient E, and betaine are on the whole conceivable outcomes, yet anticipation is in every case superior to anything treatment, so pursue an arrangement to remain healthy.
Type 2 diabetes isn't a condition you should simply live with. It require not gradually and unavoidably deteriorate. You can take control of the sickness... furthermore, reclaim your life. It begins with you...
NONALCOHOLIC FATTY LIVER DISEASE IN OBESITY AND TYPE 2 DIABETES
In the healthy state excess fat is deposited at appropriate sites, such as subcutaneous fat
depots. When fat begins to accumulate outside these regular depots, within the liver and other organs, it is named ectopic fat. To discriminate hepatic ectopic fat from fatty liver due to alcohol abuse, the condition is termed nonalcoholic fatty liver disease (NAFLD). The exact pathophysiology of NAFLD is unclear, but the deposition of ectopic fat within the liver is increased in both type 2 diabetes (T2DM) and obesity.
Accumulation of ectopic fat severely impairs hepatic metabolism and without appropriate intervention NAFLD may lead to nonalcoholic steatohepatitis (NASH) and eventually to liver cirrhosis. Resulting from the dramatic increase in patients with T2DM and obesity worldwide, cirrhosis due to nonalcoholic fatty liver disease has been predicted to become the main cause for liver transplantation by the year 2020. This poses a great need for a better understanding of the effects of ectopic liver fat on liver metabolism, new pharmacological treatment options for NAFLD and new affordable and rapid methods for early detection of liver fat accumulation in patients at high risk for NAFLD. In the current study liver fat content and glucose uptake were studied non-invasively using proton magnetic resonance spectroscopy (HMRS) and positron emission tomography (PET) in patients with T2DM, patients with obesity and healthy volunteers. Liver fat content was found to be inversely associated with liver glucose uptake in patients with T2DM and also to be associated with impaired myocardial metabolism in these patients. In addition our data indicate that liver fat content might be significantly reduced by one month Trimetazidine treatment in obese patients. Finally, we were able to develop a new rapid method, using in-and-out-of-phase MR imaging, for the non-invasive assessment of liver fat content.
NONALCOHOLIC FATTY LIVER DISEASE IN OBESITY AND TYPE 2 DIABETES - Link Download
Keywords: nonalcoholic fatty liver disease, NAFLD, liver, proton magnetic resonance
spectroscopy, 1HMRS, positron emission tomography, PET, diabetes, obesity, rosiglitazone, trimetazidine, magnetic resonance imaging, MRI
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